Nano-mechanical Reinforcement in Drug-Resistant Ovarian Cancer Cells
نویسندگان
چکیده
منابع مشابه
Nanocarriers enhance Doxorubicin uptake in drug-resistant ovarian cancer cells.
Resistance to anthracyclines and other chemotherapeutics due to P-glycoprotein (pgp)-mediated export is a frequent problem in cancer treatment. Here, we report that iron oxide-titanium dioxide core-shell nanocomposites can serve as efficient carriers for doxorubicin to overcome this common mechanism of drug resistance in cancer cells. Doxorubicin nanocarriers (DNC) increased effective drug upta...
متن کاملNano drug delivery systems for ovarian cancer therapy
Ovarian cancer is the second most common gynecologic cancer in Europe and the USA, and the most fatal gynecologic malignancy among all cancers with a mortality rate of 6%. The traditional treatment of ovarian cancer includes cytoreductive surgery and platinum-taxane combined chemotherapy. Although the response to the standard treatment scheme is promising at first, the disease often recurs and ...
متن کاملThe effect of mesoporous silica nanoparticles loaded with epirubicin on drug-resistant cancer cells
Objective (s): In chemotherapy for cancer treatment, the cell resistance to multiple anticancer drugs is the major clinical problem. In the present study, mesoporous silica nanoparticles (MSNs) were used as a carrier for epirubicin (EPI) in order to improve the cytotoxic efficacy of this drug against the P-glycoprotein (P-gp) overexpressing cell line. Materials and Methods: MSNs with phosphonat...
متن کاملJuglone exerts antitumor effect in ovarian cancer cells
Objective(s): Juglone is isolated from many species of the Juglandaceae family and used as an anti-viral, anti-bacterial, and anti-tumor therapeutic. Here, we evaluated juglone-induced antitumor effect in ovarian cancer SKOV3 cells. Materials and Methods: MTT assay was performed to examine juglone anti-proliferative effect. Cell cycle and apoptosis were studied using flow cytometry in juglone-t...
متن کاملGeneration of Cisplatin-Resistant Ovarian Cancer Cell Lines
Ovarian cancer is the most lethal gynecological cancer in which cisplatin-based treatment plays fundamental role as the first line chemotherapy option. However, development of platinum-resistance is a critical and poorly understood problem in ovarian cancer treatment. Although in vitro generation of platinum-resistant ovarian cancer cell lines is a long established approach to uncover the molec...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2015
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.b14-00604